Biosynthesis of heterocycles : from the isolation to gene cluster /
This book describes biosynthetic methods to synthesize heterocycliccompounds, offering a guide for the development of new drugs basedon natural products. The authors explain the role of naturalproducts in chemistry and their formation along with importantanalytical methods and techniques for working...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Hoboken, New Jersey :
Wiley,
[2015]
|
| Subjects: | |
| Online Access: |
Full text (MFA users only) |
| ISBN: | 9781118960424 1118960424 9781118960622 1118960629 9781118960554 1118960556 1118028678 9781118028674 |
| Local Note: | ProQuest Ebook Central |
Table of Contents:
- Cover; Contents; Preface; Acknowledgments; Chapter 1 Introduction; 1.1 Natural Products: Primary and Secondary Metabolites; 1.2 Common Reactions in Secondary Metabolites; 1.2.1 Alkylations; 1.2.2 Wagner-Meerwein Rearrangements; 1.2.3 Aldol and Claisen Reactions; 1.2.4 Schiff Base Formation and Mannich Reactions; 1.2.5 Transaminations; 1.2.6 Decarboxylations; 1.2.7 Oxidation and Reduction Reactions; 1.2.8 Dehalogenation/Halogenation Reactions; 1.2.9 Glycosylation Reactions; References; Chapter 2 Techniques for Biosynthesis; 2.1 Isotopic Labeling; 2.1.1 Stable Isotopes
- 2.1.2 Radioactive Isotopes2.2 Gene Coding for Enzymes; 2.3 Combinatorial Biosynthesis; References; Chapter 3 Three-Membered Heterocyclic Rings and Their Fused Derivatives; 3.1 Aziridines and Azirines; 3.1.1 Azicemicins; 3.1.2 Miraziridine; 3.1.3 Maduropeptin; 3.1.4 Azinomycins; 3.1.5 Ficellomycin; 3.1.6 Mitomycins; 3.1.7 Azirinomycin and Related Azirines; 3.2 Oxiranes and Oxirenes; 3.2.1 Fosfomycin; 3.2.2 AK, HC, and AF toxins; 3.2.3 Cerulenin; 3.2.4 Polyhydroxyalkanoates; 3.2.5 Epoxyrollins; 3.2.6 Asperlactone, Aspyrone, Asperline; 3.2.7 Tajixanthone; 3.2.8 Cyclomarin; 3.2.9 Cyclopenin
- 3.2.10 Ovalicin and Fumagillin3.2.11 Methylenomycin A; 3.2.12 Antibiotic LL-C10037; 3.2.13 Manumycins; 3.2.14 Scopolamine; 3.2.15 Iridoid Glucosides; 3.2.16 Cordiaquinone; 3.2.17 Cyclizidine and Indolizomycin; 3.2.18 Enediyne Antibiotics; 3.2.19 Macrolides; 3.2.20 Epothilones; 3.2.21 Pimaricin; 3.2.22 Hypothemycin; 3.2.23 Radicicol and Monocillin I; 3.2.24 Trichothecenes; 3.2.25 Sporolides A and B; References; Chapter 4 Four-Membered Heterocyclic Rings and Their Fused Derivatives; 4.1 Azetidine and Azetines; 4.1.1 Azetidine-2-carboxylic acid; 4.1.2 Polyoxins; 4.1.3 Mugineic Acids